Single-player games like Chromosome Evil 2
Below are 17 single-player Steam games similar to Chromosome Evil 2, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Chromosome Evil 2 page.
Ranked picks
- 1
Chromosome Evil
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Dive deep into this Lovecraft-inspired RTS survival. Assemble your team using different classes, skills, and weaponry. It's up to your squad to survive the onslaught of nightmares that are surely coming your way. Will you find the source of the darkness?
- 2
Welcome Back, Commander
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Commander, your strike team is to dive deep into the contaminated city of Sun Stone and get some answers before the mysterious deadly plague spreads . Good luck Commander!
- 3
Aliens: Dark Descent
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Drop into the gripping journey of Aliens: Dark Descent, a squad-based, single-player action game in the iconic Alien franchise. Lead your soldiers in real-time to stop a new and terrifying kind of Xenomorph outbreak on Planet Lethe.
- 4
Dead in Antares
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Dead in Antares is a turn-based survival management game with RPG elements, set on an alien planet. Lead a crew of survivors sent on a mission to save humanity. Manage their needs, strengthen their teamwork, and explore this mysterious world to find a way back home.
- 5
Cataclysm: Dark Days Ahead
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares RPG with Chromosome Evil 2.
The epitome of a modern traditional roguelike: with turn-based play and a RPG-like skill progression system, it hearkens back to some of the major aspects of this genre. This game has an incredible depth, with a deep inventory system, vehicles and boats, NPCs with their own stories, and more.
- 6
Don't Starve Together
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Fight, Farm, Build and Explore Together in the standalone multiplayer expansion to the uncompromising wilderness survival game, Don't Starve.
- 7
Phoenix Point
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy and RPG with Chromosome Evil 2.
The acclaimed strategy game from the creator of X-COM. Fight tactical battles on procedural maps against a foe that adapts to your tactics. Manage diplomacy and economy on a global scale. Research, explore, overcome. Now includes Steam Workshop support for mods!
- 8
Quasimorph: End of Dream
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy and RPG with Chromosome Evil 2.
Quasimorph: End of Dream is the first chapter of the extraction turn-based RPG Quasimorph. Confront your fears in brutal shootouts with PMC -fighters and demons and try to survive to complete your mission and bring the gear back to your spaceship!
- 9
Strain Tactics
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Strain Tactics is a real-time-with-pause tactical game, where you command a squad of soldiers to liberate earth from an alien infestation. Using your helibase, deploy your custom squad and provide air support. Remember to keep your crew sane and motivated while staying clear of alien contamination!
- 10
Xenonauts
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Xenonauts is a strategy game in which you control a multi-national military organisation defending a Cold War-era Earth from alien invasion, using small squads of persistent soldiers to eliminate the extraterrestrials and recover their technology in turn-based ground combat.
- 11
Xenonauts 2
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy and RPG with Chromosome Evil 2.
Wage a global war of resistance against an alien invasion. Command turn-based tactical battles, build a network of covert bases, directly control your fighter wings, and achieve strategic victory in a simulation of asymmetric warfare against a technologically superior foe.
- 12
SAS: Zombie Assault 4
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares RPG with Chromosome Evil 2.
Purge the undead! Intense action-shooter with deep rpg elements, including upgradeable guns and armor, unique class skills, and class special abilities. Entire game can be played single player or as a 4-player online co-op game, including PvP events like Last Man Standing.
- 13
XCOM® 2
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
XCOM 2 is the sequel to XCOM: Enemy Unknown, the 2012 award-winning strategy game of the year. Earth has changed and is now under alien rule. Facing impossible odds you must rebuild XCOM, and ignite a global resistance to reclaim our world and save humanity.
- 14
Flesh Eaters
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
Flesh Eaters is retro style single player RTS zombie survival game with resource gathering and crafting. Zombies are everywhere! You must gather resources to build barricades, upgrade weapons and armour and explore the city under the siege of the dead
- 15
TAURONOS
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
Trapped inside an ancient labyrinth, chased by the mythical Minotaur. Will you reach the center? And if so, what will you discover about yourself there, in the dark?
- 16
Desolated District
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
Desolated District is an Open-World Survival Crafting game set in a post-apocalyptic dystopia. Scavenge for resources, craft essential tools, build your base and battle deadly threats as you explore a sprawling, decaying city inspired by the Kowloon Walled City.
- 17
TD Fade to Dark
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
A dark Tower Defense and Survival hybrid where your only currency is time, and how you choose to use. Step into the dark forest, build your defenses during the day, explore, and during the night make every second count before the monsters find you.