Single-player games like Chromosome Evil 2
Below are 19 single-player Steam games similar to Chromosome Evil 2, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Chromosome Evil 2 page.
Ranked picks
- 1
Aliens: Dark Descent
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Drop into the gripping journey of Aliens: Dark Descent, a squad-based, single-player action game in the iconic Alien franchise. Lead your soldiers in real-time to stop a new and terrifying kind of Xenomorph outbreak on Planet Lethe.
- 2
Monsters In The Shadows
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Low-poly horror fps survival shooter game. Kill monsters hidden within the walls of an abandoned city.
- 3
Project: Aurora
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy and RPG with Chromosome Evil 2.
Aurora isn't as desolate as it seems. Survive amidst storms, lost technologies, and remnants of a vanished civilization—before you become part of them.Aurora is not as abandoned as it seems. As in classic sci-fi, discovering its secret means confronting the depths of cosmic horror.
- 4
Darkwood
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy and RPG with Chromosome Evil 2.
Darkwood - a new perspective on survival horror. Scavenge and explore a rich, ever-changing free-roam world by day, then hunker down in your hideout and pray for the morning light.
- 5
Zafehouse Diaries 2
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy and RPG with Chromosome Evil 2.
Zafehouse Diaries 2 is a game of survival, exploration and relationships. Every hour, designate tasks for your handful of characters - each with their own skills, motivations and prejudices - and try to outlast the zombie apocalypse.
- 6
Expedition: Shadow World
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Expedition: Shadow World is a tactical game about an expedition sent to a distant planet to extract energy resources. Command a group of five troopers in real-time battles with a tactical pause and discover the mystery of the planet.
- 7
Xenoids
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
Xenoids is a survival horror game where you have to face a hostile life form in the confined space of a spaceship.
- 8
Chromosome Evil
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Dive deep into this Lovecraft-inspired RTS survival. Assemble your team using different classes, skills, and weaponry. It's up to your squad to survive the onslaught of nightmares that are surely coming your way. Will you find the source of the darkness?
- 9
Strain Tactics
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Strain Tactics is a real-time-with-pause tactical game, where you command a squad of soldiers to liberate earth from an alien infestation. Using your helibase, deploy your custom squad and provide air support. Remember to keep your crew sane and motivated while staying clear of alien contamination!
- 10
Xenonauts
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Xenonauts is a strategy game in which you control a multi-national military organisation defending a Cold War-era Earth from alien invasion, using small squads of persistent soldiers to eliminate the extraterrestrials and recover their technology in turn-based ground combat.
- 11
Killing Floor
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
6-player co-op survival horror at its finest! Free updates, free special events and a ridiculous amount of fun!
- 12
Xenonauts 2
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy and RPG with Chromosome Evil 2.
Wage a global war of resistance against an alien invasion. Command turn-based tactical battles, build a network of covert bases, directly control your fighter wings, and achieve strategic victory in a simulation of asymmetric warfare against a technologically superior foe.
- 13
SAS: Zombie Assault 4
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares RPG with Chromosome Evil 2.
Purge the undead! Intense action-shooter with deep rpg elements, including upgradeable guns and armor, unique class skills, and class special abilities. Entire game can be played single player or as a 4-player online co-op game, including PvP events like Last Man Standing.
- 14
XCOM® 2
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
XCOM 2 is the sequel to XCOM: Enemy Unknown, the 2012 award-winning strategy game of the year. Earth has changed and is now under alien rule. Facing impossible odds you must rebuild XCOM, and ignite a global resistance to reclaim our world and save humanity.
- 15
The Bureau: XCOM Declassified
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
The year is 1962 and the Cold War has the nation gripped by fear. A top-secret government unit called The Bureau begins investigating a series of mysterious attacks by an enemy more powerful than communism.
- 16
Flesh Eaters
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
Flesh Eaters is retro style single player RTS zombie survival game with resource gathering and crafting. Zombies are everywhere! You must gather resources to build barricades, upgrade weapons and armour and explore the city under the siege of the dead
- 17
Welcome Back, Commander
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil 2.
Commander, your strike team is to dive deep into the contaminated city of Sun Stone and get some answers before the mysterious deadly plague spreads . Good luck Commander!
- 18
TAURONOS
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
Trapped inside an ancient labyrinth, chased by the mythical Minotaur. Will you reach the center? And if so, what will you discover about yourself there, in the dark?
- 19
Desolated District
Single-player alternative to Chromosome Evil 2 — playable solo, no multiplayer required.
Desolated District is an Open-World Survival Crafting game set in a post-apocalyptic dystopia. Scavenge for resources, craft essential tools, build your base and battle deadly threats as you explore a sprawling, decaying city inspired by the Kowloon Walled City.