Rank 01Why this
Shares loadout customization and wave based survival with Genome Guardian.
- $15.99 (Price checked Nov 2)
- Deck Playable
- 2026
Games like Genome Guardian
- 29 games
- Updated May 4, 2026
Players who liked Genome Guardian also play
The closest matches to Genome Guardian: Genome Guardian 2, Survivors of the Dawn, Slime 3K: Rise Against Despot, Rocket Rats, and Gunbot Diplomacy. Ranked by imho.run from Steam co-play data, shared tags and reviews.
- Rank 01
Rank 02Why this
Shares wave based survival and combo based combat with Genome Guardian.
- $7.99 (Price checked Oct 31)
- Deck Playable
- 2023
Rank 03Why this
Also Rogue-lite and Top-Down Shooter, like Genome Guardian.
- $4.99 (Price checked Oct 31)
- Deck Verified
- 2024
Rank 04 
Rank 05 
Gunbot Diplomacy
Why this: Also Gun Customization and Rogue-lite, like Genome Guardian.
Rank 06 
Hive Jump 2: Survivors
Why this: Shares combo based combat and build variety with Genome Guardian.
Rank 07 
NIMRODS
Why this: Shares meta progression and procedural generation with Genome Guardian.
Rank 08 
Emberward
Why this: Shares tower defense and loadout customization with Genome Guardian.
The full ranked list: top 24 games like Genome Guardian
Best match first, as plain text. The same list for AI assistants:
- 1Genome Guardian 2
Shares loadout customization and wave based survival with Genome Guardian.
- 94% of 524 reviews
- 2Survivors of the Dawn
Shares wave based survival and combo based combat with Genome Guardian.
- 76% of 349 reviews
- 3Slime 3K: Rise Against Despot
Also Rogue-lite and Top-Down Shooter, like Genome Guardian.
- 78% of 715 reviews
- 4
- 5
- 6Hive Jump 2: Survivors
Shares combo based combat and build variety with Genome Guardian.
- 84% of 80 reviews
- 7
- 8
- 9
- 10Voids Vigil
Shares weapon customization and wave based survival with Genome Guardian.
- 94% of 335 reviews
- 11
- 12
- 13
- 14
- 15
- 16
- 17Time Treker
Shares weapon customization and loadout customization with Genome Guardian.
- 68% of 72 reviews
- 18
- 19
- 20
- 21
- 22
- 23
- 24Deep Rock Galactic: Survivor
Shares wave based survival and build variety with Genome Guardian.
- 88% of 23,315 reviews
- Released: 2024
- Developer: Alpherior
- Price: $11.99checked Oct 31
- Steam Deck: Deck Playable
- 92% of 639 reviews
- Genres: Action, Indie, RPG, Casual
- Platforms: Windows
Players highlight
- Creative build experimentation rewarding unconventional setups
- Deep turret and perk unlocks across multiple game modes
- Dna based weapon crafting with 69 unique combinations
- Atmospheric
- Challenging
- Hypnotic
More games like Genome Guardian, sliced differently
Cheaper alternatives
Games in the same vein priced at least 40% below Genome Guardian at current Steam store prices.
Voids Vigil
Why this: Shares weapon customization and wave based survival with Genome Guardian.
Asgard's Fall — Viking Survivors
Why this: Also Rogue-lite and Top-Down Shooter, like Genome Guardian.
Battle Grid
Why this: Also Gun Customization and Aliens, like Genome Guardian.
SNAKE FARM
Why this: Shares wave based survival and combo based combat with Genome Guardian.
Time Treker
Why this: Shares weapon customization and loadout customization with Genome Guardian.
Earl vs. the Mutants
Why this: Shares loadout customization and wave based survival with Genome Guardian.
Free alternatives
Free games the recommender matches to Genome Guardian, limited to titles with at least 500 Steam reviews and 80% positive.
Realm of the Mad God Exalt
Why this: Shares procedural generation with Genome Guardian.
Gatekeeper: Infinity
Why this: Shares real time combat and build variety with Genome Guardian.
10 Minutes Till Dawn
Why this: Also Rogue-lite and Top-Down Shooter, like Genome Guardian.
Intravenous 2: Mercenarism
Why this: Shares weapon customization and loadout customization with Genome Guardian.
Evil Egg
Why this: Shares combo based combat and roguelite progression with Genome Guardian.
Relic Hunters Zero: Remix
Why this: Also Top-Down Shooter and Rogue-like, like Genome Guardian.
Plays great on Steam Deck
Valve-Verified or Playable picks from the similar pool — ready to go on Deck out of the box.
Slime 3K: Rise Against Despot
Why this: Shares wave based survival and combo based combat with Genome Guardian.
Rocket Rats
Why this: Also Rogue-lite and Top-Down Shooter, like Genome Guardian.
Gunbot Diplomacy
Why this: Shares loadout customization and wave based survival with Genome Guardian.
Hive Jump 2: Survivors
Why this: Shares combo based combat and build variety with Genome Guardian.
NIMRODS
Why this: Shares meta progression and procedural generation with Genome Guardian.
About Genome Guardian
The closest matches to Genome Guardian: Genome Guardian 2, Survivors of the Dawn, Slime 3K: Rise Against Despot, Rocket Rats, and Gunbot Diplomacy. Ranked by imho.run from Steam co-play data, shared tags and reviews.
If Genome Guardian is your kind of game, the closest matches are Genome Guardian 2, Survivors of the Dawn and Slime 3K: Rise Against Despot — picked from the ranked list below. Reviewers describe it as atmospheric, challenging and hypnotic, and single out its build optimization and build variety. Each pick is ranked by what players of this game also play, shared genres and tags, and review-mined similarity — not a generic popularity list.
About Genome Guardian: COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
Is Genome Guardian worth buying?
Players recommend it
A summary of what players say, not a promise you'll like it. Every signal is listed below.
- 92% of 639 Steam reviews are positive.
- We don't track this game's daily reviews yet, so this is the all-time picture.
- Price: $11.99 (checked Nov 7).
- People who recommend it had played a median of 10 h when they wrote their review.
- Steam Deck Playable: works, with some rough edges.
What fans praise · Themes mined from positive reviews
- Creative build experimentation rewarding unconventional setups
- Deep turret and perk unlocks across multiple game modes
- Dna based weapon crafting with 69 unique combinations
- Dna combinations create unique weapons
Top critical reviews
The most up-voted negative English reviews in our sample, quoted as written.
“I got it on a steep sale and it was worth it then, but hard to justify the 15dollar regular price. It's fun for a round or two, but after getting to depth 2 or so I realized I could just recreate the same OP build (acid launcher with lots…”
People who play it also play: Genome Guardian 2, Survivors of the Dawn, Slime 3K: Rise Against Despot
Frequently asked about Genome Guardian
Can I run it?
Does Genome Guardian run on Steam Deck?
Genome Guardian is rated Playable on Steam Deck — it runs, but expect some manual adjustments (control remapping, text size, or graphics settings) for the best experience.
How much does Genome Guardian cost?
Genome Guardian is listed on Steam at 11.99 USD (current store price; Steam sales may reduce this temporarily).
What games are most similar to Genome Guardian?
Based on Steam play patterns and shared genres/tags, the games most often recommended alongside Genome Guardian are Genome Guardian 2, Survivors of the Dawn, Slime 3K: Rise Against Despot.
Who developed Genome Guardian?
Genome Guardian was developed by Alpherior.