Single-player games like Genome Guardian
Below are 9 single-player Steam games similar to Genome Guardian, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Genome Guardian page.
Ranked picks
- 1
Genome Guardian 2
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!
- 2
Survivors of the Dawn
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
A roguelite horde-survival bullet heaven with QUINTILLIONS of bullets over QUINTILLIONS of hordes. Mix weapons with items, modify, control chaos at terminals and break through tightening waves.
- 3
Slime 3K: Rise Against Despot
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
Welcome to Slime 3K, an unhinged roguelite bullet-heaven set in the Despot’s Game universe! Build a deck of crazy weapons, grow stronger and devour hordes of pink puny humans as a murderous jelly blob on a warpath of death, violence and pretzels.
- 4
Rocket Rats
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Casual with Genome Guardian.
Rocket Rats is a survivors-like game where you defeat cheese-based astral bodies in space – as a rat! Clear waves of enemies, collect cheese, upgrade your gear, and conquer the moon!
- 5
Gunbot Diplomacy
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
Splatter slimes, massacre mutants, and assemble your perfect Gunbot! Survive hordes of enemies in this top-down shooter roguelite by customizing your weapons on the unique upgrade grid, and pick from a wide variety of build-defining modules and wacky base bots for a new experience every run.
- 6
Hive Jump 2: Survivors
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
Become an agent of vengeance in this bullet-heaven action roguelite! You are the lone survivor of your squad, on an alien planet with just your weapon, a jetpack, and the courage to keep fighting. Kill off alien swarms and transform their valuable guts into explosive upgrades and vital utilities.
- 7
NIMRODS
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
Assemble a limitless arsenal in this survive-em-up roguelite shooter. As a Gun Manufacturer's testing force, your mission is simple: test the latest gun tech and scavenge alien planets. Collect insane weapon parts to invent crazy guns that slay thousands. You may not survive, but your guns will!
- 8
Emberward
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Indie with Genome Guardian.
Build twisting mazes with tetromino blocks and deploy unique towers in this strategic roguelite tower defense adventure!
- 9
Cell Command
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Indie and RPG with Genome Guardian.
TURN-BASED TACTICS meets SNAKE: A new roguelike in the Genome Guardian universe. SPLICE DNA to create new units, enhance their genetics, and take on the Abyss virus once more in a variety of different modes & match types.