Single-player games like Genome Guardian
Below are 10 single-player Steam games similar to Genome Guardian, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Genome Guardian page.
Ranked picks
- 1
Genome Guardian 2
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!
- 2
Hive Jump 2: Survivors
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
Become an agent of vengeance in this bullet-heaven action roguelite! You are the lone survivor of your squad, on an alien planet with just your weapon, a jetpack, and the courage to keep fighting. Kill off alien swarms and transform their valuable guts into explosive upgrades and vital utilities.
- 3
NIMRODS
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
Assemble a limitless arsenal in this survive-em-up roguelite shooter. As a Gun Manufacturer's testing force, your mission is simple: test the latest gun tech and scavenge alien planets. Collect insane weapon parts to invent crazy guns that slay thousands. You may not survive, but your guns will!
- 4
Nuclear Throne
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
Nuclear Throne is a post-apocalyptic roguelike-like top-down shooter. Not 'the final hope of humanity' post-apocalyptic, but 'humanity is extinct and mutants and monsters now roam the world' post-apocalyptic. Can you reach the Nuclear Throne?
- 5
Defend Earth: Xenos Survivors
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
You are Earth's last line of defense in a relentless alien invasion. Experience intense top-down roguelite action across diverse landscapes, fighting invaders with a versatile arsenal. Outsmart, outgun, and survive your foes. Every run increases the challenge - so adapt, evolve, dominate!
- 6
Brotato
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
Brotato is a top-down arena shooter roguelite where you play a potato wielding up to 6 weapons at a time to fight off hordes of aliens. Choose from a variety of traits and items to create unique builds and survive until help arrives.
- 7
Rocket Rats
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Casual with Genome Guardian.
Rocket Rats is a survivors-like game where you defeat cheese-based astral bodies in space – as a rat! Clear waves of enemies, collect cheese, upgrade your gear, and conquer the moon!
- 8
Atomicrops
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
A twin-stick, bullet-hell, roguelite where you must cultivate and defend the last farm in a post-apocalyptic wasteland. Farm mutated crops, upgrade your weapons, marry townsfolk, and kill every mutant creature that tries to invade your homestead! Yee-haw!
- 9
Terraria
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian.
Dig, fight, explore, build! Nothing is impossible in this action-packed adventure game. Four Pack also available!
- 10
Cell Command
Single-player alternative to Genome Guardian — playable solo, no multiplayer required. Shares Indie and RPG with Genome Guardian.
TURN-BASED TACTICS meets SNAKE: A new roguelike in the Genome Guardian universe. SPLICE DNA to create new units, enhance their genetics, and take on the Abyss virus once more in a variety of different modes & match types.