Single-player games like Genome Guardian 2
Below are 11 single-player Steam games similar to Genome Guardian 2, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Genome Guardian 2 page.
Ranked picks
- 1
Compadrone: Land Wars
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian 2.
In this fast-paced roguelite arena shooter with tower-defense twists, control a drone capable of wielding multiple weapons and fight hordes of alien warbots. Collect resources and XP to unlock new weapons, towers, abilities, and drones.
- 2
Supre-Immune
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian 2.
Join a roguelike action where cute immune cells battle viruses. Collect data in fast-paced combat, gain weapons and abilities through evolution, or level up to grow stronger. The fun of building your own super immune cell with different combinations each run is up to you!
- 3
Deep Breach
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian 2.
Deploy orbital defenses, fuse experimental turret technologies, and engineer devastating weapon builds in a tactical sci-fi horde survival roguelike. Break shields, shred armor, and adapt to evolving bio-corrupted swarms alongside a damaged tactical AI.
- 4
Genome Guardian
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian 2.
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
- 5
Lost Galaxy: Survivors
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Action and Casual with Genome Guardian 2.
Defend massive interdimensional portals against relentless alien swarms in this fast-paced sci-fi top-down survival shooter.
- 6
MassEve
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian 2.
You are a massive neutrino. Craft quantum builds, clash with other subatomic particles, and survive a universe that reshapes every run. A fast-paced twin-stick roguelike where real physics bends the rules.
- 7
Tankron
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian 2.
Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.
- 8
Cosmic Flesh: Overdrive
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian 2.
Defend the galaxy from endless cosmic horrors. Dash and blast with fast, burst-based piloting, unleash powerful overdrives, evolve your ship with each unique run, and push your skills to the limit.
- 9
Nova Drift
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Action and Indie with Genome Guardian 2.
Nova Drift distills the mechanical depth and strategy of an ARPG into classic arcade space combat. Control an endlessly evolving bio-mechanical ship, face legions of strange and deadly foes, and ride the wake of a dying star across the void.
- 10
Balatro
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Indie and Casual with Genome Guardian 2.
The poker roguelike. Balatro is a hypnotically satisfying deckbuilder where you play illegal poker hands, discover game-changing jokers, and trigger adrenaline-pumping, outrageous combos.
- 11
Cell Command
Single-player alternative to Genome Guardian 2 — playable solo, no multiplayer required. Shares Indie and RPG with Genome Guardian 2.
TURN-BASED TACTICS meets SNAKE: A new roguelike in the Genome Guardian universe. SPLICE DNA to create new units, enhance their genetics, and take on the Abyss virus once more in a variety of different modes & match types.